RAF Typhoon jets have operated alongside France's air force in a joint strike on an hidden munitions depot in Syria operated by the IS group, per a report from the UK Ministry of Defence.
The location, pinpointed through surveillance, was assessed as housing weapons and explosive materials, the announcement noted, and was located in mountainous terrain just north of the historic site of Palmyra in the heart of Syria.
"Our fighter planes utilized precision-guided Paveway IV munitions to target a number of approach shafts leading to the depot... initial indications are that the target was engaged successfully," the MoD said.
There was no indication of any harm to civilians in the attack conducted Saturday night and all the aircraft returned to base without incident, the MoD added.
The British jets were backed up by a Voyager refuelling tanker.
IS - also known as Daesh - enforced militant control over large swathes of Syria and Iraq until 2019.
"This operation shows the UK's leading role, and determination to work closely with our allies, to eradicate any revival of IS and their dangerous and violent ideologies in the region," the British Defence Secretary John Healey stated.
British military aircraft have conducted surveillance missions over Syrian airspace to "deter any efforts to regroup" of Islamic State subsequent to its routing at the Baghuz confrontation in 2019, the MoD reported.
"I want to thank every member of British forces participating in this operation for their professionalism and their courage," the Defence Secretary added. "They were part of numerous UK service members stationed over Christmas and New Year. This mission, to take out dangerous terrorists who endanger our way of life, shows how UK forces are always on standby, all year round, keeping Britain secure at home and influential overseas."
Last December, the American forces conducted what it described as a "large-scale strike" targeting Daesh sites in the country, after an ambush killed two US servicemembers and a civilian linguist in Palmyra.
The UN reports Islamic State still maintains roughly 5-7 thousand combatants in Iraq and Syria.